06 Dec 2016
Albumedix and NYU School of Medicine to Investigate Targeting Novel Cellular Pathways in Oncology
Press Release: Copenhagen, Denmark, New York, NY - December 6th 2016 – Today Albumedix announced that they have entered into a collaborative research agreement with the New York University (NYU) School of Medicine. The collaboration will explore the potential of novel applications of Albumedix’ albumin-based drug delivery platform, Veltis®, to modulate immune pathways discovered at NYU.
The research collaboration carried out at both the NYU School of Medicine in New York, USA and at the Albumedix research facility in Nottingham, UK, aims to investigate the potential of Albumedix’ engineered albumin-drug constructs as immuno-oncology therapies using novel immunomodulatory pathways. From NYU, the collaboration will be led by Dr. Dafna Bar-Sagi, Vice Dean for Science and Chief Scientific Officer at NYU Langone Medical Center. Dr. Bar-Sagi is one of the country’s leading cancer biologists, whose research has had a major impact on the understanding of mechanisms that control tumor initiation and progression. She is widely known for her work on the Ras oncogene and its role in the regulation of cell proliferation and survival, cancer metabolism, and tumor immunity.
Despite significant advancements in treatment options, cancer remains one of the leading causes of morbidity and mortality worldwide. Increasing understanding of the underlying tumor biology in patients is a cornerstone of cancer research and drug development efforts. As part of the collaboration, Dr. Bar-Sagi’s laboratory will be responsible for evaluating the immuno-modulatory effect of albumin-drug constructs developed by Albumedix against various pathways involved in the response of immune cells to specific forms of cancer.
“Albumin-based therapies have already offered important benefits to patients worldwide. This collaboration enables us to take another step towards broadening their therapeutic potential,” comments Dr. Darrell Sleep, Chief Scientific Officer at Albumedix. “Dr. Bar-Sagi and her team are renowned experts who bring an extraordinary understanding of oncology to this collaboration. We are excited to work with them to elucidate the potential therapeutic role of our Veltis® technology in oncology.”
Commenting on the collaboration, Dr. Bar-Sagi said: “Here at NYU, we have recently identified a number of novel and exciting immunomodulatory pathways in cancer. We look forward to exploring how such pathways can be targeted therapeutically using Albumedix’ technology.“
Albumedix has developed Veltis® a technology platform based on recombinant human albumin variants engineered to improve the therapeutic half-life of APIs connected to Veltis® and increase its drug payload capacity. The use of albumin to extend the half-life of therapeutic proteins has been clinically validated through the approvals of GSK’s Tanzeum® (GLP-1/albumin fusion for Type 2 Diabetes) and CSL’s Idelvion® (rhFactor IX/albumin fusion for Hemophilia). In parallel, Albumedix has been exploring the potential benefits of its Veltis® technology in oncology applications. This research collaboration will help expand the mechanistic understanding of how albumin may play a role in facilitating cancer immune regulation.
This agreement will not impact the 2016 results and 2017 financial forecast for Albumedix’ parent company, Novozymes.
Dedicated to Better Health, we partner with excellence to improve therapies for people with serious diseases. We are proud to be recognized as the world leader in recombinant human albumin. We are as passionate about albumin and albumin enabled therapies today as we were when we started 30 years ago. Albumedix is a global company, headquartered in Kgs. Lyngby, Denmark, with production and R&D in Nottingham, England, we are more than 100 people, all committed to improving patient quality of life. Albumedix is a fully owned subsidiary of Novozymes A/S. For further information, please visit www.albumedix.com, LinkedIn.
About the New York University School of Medicine
The NYU School of Medicine (http://school.med.nyu.edu/) is one of the nation’s preeminent academic institutions dedicated to achieving medical education excellence. For 170 years, NYU School of Medicine has trained thousands of physicians and scientists who have helped to shape the course of medical history and enrich the lives of countless people. NYU School of Medicine has approximately $260 million in annual research funding and is a leader amongst universities in developing numerous biomedical products including those currently advancing in drug discovery and development, as well as approved blockbuster drugs that have been used to treat over two million patients worldwide.
Jonas Skjødt Møller
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