Serial coupling of ion-exchange and size-exclusion chromatography to determine aggregation levels in mAbs in the presence of a proteinaceous excipient, recombinant human serum albumin
Weisbjerg PL, Caspersen MB, Cook K, Van De Weert M.
J Pharm Sci. 2015 Feb;104(2):548-56. doi: 10.1002/jps.24275. Epub 2014 Dec
Pub type: Recombumin®
"We performed a feasibility study of using serial coupling of an anion exchange and size exclusion column to determine the aggregation levels of four different model monoclonal antibodies (mAb) mixed with the model proteinaceous excipient recombinant human serum albumin (rHSA)"