Cellular recycling-driven in vivo half-life extension using recombinant albumin fusions tuned for neonatal Fc receptor (FcRn) engagement
Maja Thim Larsena, Helen Rawsthorneb, Karen Kræmmer Scheldea, Frederik Dagnæs-Hansenc, Jason Cameronb, Kenneth A. Howarda
October 10th 2018
Journal of Controlled Release 287 (2018) 132–141
"In this work, we have used a panel of recombinant fusions, engineered with different human FcRn (hFcRn) affinity, including a novel high binding albumin variant (HBII), to directly define and importantly, control the intracellular mechanism as a half-life extension tuning method."