Structure-based mutagenesis reveals the albumin-binding site of the neonatal Fc receptor
Jan Terje Andersen, Bjørn Dalhus, Jason Cameron, Muluneh Bekele Daba,Andrew Plumridge,Leslie Evans,Stephan O. Brennan,Kristin Støen Gunnarsen, Magnar Bjørås, Darrell Sleep, Inger Sandlie
Nature Communications 2012 3,(610) doi:10.1038/ncomms1607 Published 03 January 2012
Pub type: co-authored VELTIS
"Here we present structure-based modelling of the FcRn–albumin complex, supported by binding analysis of site-specific mutants, providing mechanistic evidence for the presence of pH-sensitive ionic networks at the interaction interface. These networks involve conserved histidines in both FcRn and albumin domain III."