Unraveling the Interaction between FcRn and Albumin: Opportunities for Design of Albumin-Based Therapeutics
Kine Marita Knudsen Sand,1,2 Malin Bern,1,2 Jeannette Nilsen,2,3 Hanna Theodora Noordzij,1,2 Inger Sandlie,1,2 and Jan Terje Andersen2
Front Immunol. 2014; 5: 682. Published online 2015 Jan 26. doi: 10.3389/fimmu.2014.00682
Pub Type: Third Party (Oslo –K573P) VELTIS
"The neonatal Fc receptor (FcRn) was first found to be responsible for transporting antibodies of the immunoglobulin G (IgG) class from the mother to the fetus or neonate as well as for protecting IgG from intracellular catabolism. However, it has now become apparent that the same receptor also binds albumin and plays a fundamental role in homeostatic regulation of both IgG and albumin, as FcRn is expressed in many different cell types and organs at diverse body sites."