Optimizing cell therapy performance
Cell therapies, including immune cell and stem cell-based therapies, are some of the most sophisticated therapeutics in development. At the scientific forefront of medical research, cell therapy offers an attractive alternative approach to more widely used treatment options. However, the area faces challenges on several fronts, such as upscaling, logistics and ensuring consistent performance. Consequently, there is a need to optimize cell performance to achieve a viable cell product and safe therapeutic solution to patients.
Recombinant human albumin for stem cell culture, cryopreservation & formulation
Albumin is a long-established ingredient of cell culture media, well known to facilitate growth of many cell types, such as mesenchymal stem cells (MSC’s), embryonic stem cells (ESC’s), induced pluripotent stem cells (iPSC’s) and immune cells.
The exact role of albumin in cell culture is not fully established, however after decades of use, its relevance and benefits in cell therapy applications cannot be disputed. Today, several of albumin’s biological properties have been proven valuable across the cell therapy value chain, including:
- Transportation and complexation with metals or other beneficial molecular entities, creating an optimal micro-environment for sustained cell viability.
- Acting as a rich nutrient source ensuring optimal conditions, particularly during cell proliferation.
- Functioning as a pH buffer to prevent unwanted effects during differentiation.
- Maintaining cell viability during cryopreservation - driven by the high purity of our recombinant albumin.
- Acting as a scavenger of toxins and other reactive oxygen species, albumin protects cells against chemical stress all the way from culture to patient.
- Providing an insulation effect in media due to its propensity to distribute evenly throughout solutions.
The actual function of albumin in cell culture, cryopreservation and stem cell formulation is believed to be a combination of these properties. Our recombinant human albumin products (Recombumin®) has been specifically developed to enhance these functional properties – giving you more confidence in your cell therapy.
Read more about albumin in cell therapy in our webinar or whitepaper (Bookshelf)