Protein & peptide formulation
Given the unstable nature of proteins and peptides, optimizing the stability of such therapeutics is a critical yet challenging objective of any drug development program. Resolution of such challenges enables their full therapeutic potential to be exploited, thereby ensuring optimal treatment options.
Safety and activity can be impaired by loss of “integrity” of the formulated product. Proteins and peptides indeed are only marginally stable and can undergo degradation via several mechanisms:
Choosing the right formulation strategy
Companies often work within a standard toolbox of excipients for formulation development. Although many of these agents are effective stabilizers, their use requires careful consideration in terms of local toxicity and potential immunogenicity. Often the outcome is a cocktail of excipients. In some instances, it is quite difficult to combine the various “ingredients” to reach the levels of stabilization needed. As formulation becomes increasingly complicated to achieve, there is an equally increased need for advanced solutions.
Albumin is nature’s own stabilizer, with in vivo functions to transport and protect vital molecules. Our recombinant human albumin, Recombumin® exploits albumin’s multifunctional properties as an effective, versatile stabilizer. It is particularly suited as a leaner formulation approach of biological drugs, such as proteins or peptides, not readily stabilized using traditional formulation strategies.
Read more about albumin in protein or peptide formulation in our scientific library